SEOM–GOTEL clinical guidelines on diffuse large B-cell lymphoma (update 2025)
Diffuse large B-cell lymphoma (DLBCL) is the most frequent histological subtype of non-Hodgkin lymphoma and the paradigm for the management of aggressive lymphoma. An excisional or incisional lymph node biopsy evaluated by an experienced hematopathologist is recommended to establish the diagnosis. Twenty years following its introduction, the combination of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) remains the standard first-line treatment. No modification of this scheme (increased chemotherapy dose intensity, new monoclonal antibodies, or the addition of immunomodulators or anti-target agents) has significantly improved the clinical outcomes, whereas therapy for recurrence or progression is evolving rapidly. The introduction of chimeric antigen receptor T cells, polatuzumab vedotin, tafasitamab, and cluster of differentiation (CD)20/CD3 bispecific antibodies is changing the natural history of patients with relapsed DLBCL and will challenge R-CHOP as the benchmark for newly diagnosed patients. These updated guidelines (2025) summarize current evidence and available therapies for the medical management of DLBCL.
Authors
- Ramón García-Arroyo
- Virginia Calvo (ORCID: https://orcid.org/0000-0002-3503-4847)
- Marta Llanos (ORCID: https://orcid.org/0000-0002-4876-5075)
- José Gómez‐Codina
- Josep Gumà (ORCID: https://orcid.org/0000-0001-7541-9832)
- Natalia Palazón‐Carrión (ORCID: https://orcid.org/0000-0001-7698-9503)
- Silvia Sequero (ORCID: https://orcid.org/0000-0002-7432-4636)
- Antonio Rueda‐Domínguez (ORCID: https://orcid.org/0000-0001-5890-0149)
- Mariano Provencio (ORCID: https://orcid.org/0000-0001-6315-7919)
- Natividad Martínez-Banaclocha (ORCID: https://orcid.org/0000-0002-7515-5037)
Institutions
- Hospital Universitario de Canarias (ES)
- Hospital Universitari i Politècnic La Fe (ES)
- Hospital Universitario Virgen Macarena (ES)
- Institut de Recerca Biomèdica Catalunya Sud (ES)
- Hospital Universitario Puerta de Hierro Majadahonda (ES)
- Instituto de Investigación Biosanitaria de Granada (ES)
- Hospital General Universitario de Alicante Doctor Balmis (ES)
- Hospital Universitari Sant Joan de Reus (ES)
- Hospital Clínico Universitario Virgen de la Victoria (ES)
- Complejo Hospitalario de Pontevedra (ES)
- Instituto de Investigación Biomédica de Málaga (ES)
Publication Details
- Journal
- Clinical & Translational Oncology
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1007/s12094-025-04080-z
- Primary Topic
- Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Sociedad Española de Oncología Médica