Formation of metabolic water by aerobic glucose oxidation

A recent paper suggests that the water originating from the ATP production coupled to aerobic glucose oxidation causes more than a 6 fold increase in the production of metabolic water, compared with the standard textbook description of the oxidation process. However, the authors seem to have forgotten that the simultaneous processes of ATP utilization takes up the same amount of water, which was liberated during the ATP synthesis. Thus, at steady state, there is no net increase in the production of metabolic water.

Authors

Institutions

Publication Details

Journal
Fluids and Barriers of the CNS
Published
2025-10-23
DOI
https://doi.org/10.1186/s12987-025-00712-2
Citations
2
Primary Topic
Diet, Metabolism, and Disease
Type
article
Field-Weighted Citation Impact
2.59
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Formation of metabolic water by aerobic glucose oxidation

Bjørn Quistorff
2 citations
Fluids and Barriers of the CNS
Diet, Metabolism, and Disease
2.59
article

Formation of metabolic water by aerobic glucose oxidation

Bjørn Quistorff
article en
2 citations

Abstract

A recent paper suggests that the water originating from the ATP production coupled to aerobic glucose oxidation causes more than a 6 fold increase in the production of metabolic water, compared with the standard textbook description of the oxidation process. However, the authors seem to have forgotten that the simultaneous processes of ATP utilization takes up the same amount of water, which was liberated during the ATP synthesis. Thus, at steady state, there is no net increase in the production of metabolic water.

Fluids and Barriers of the CNSVol. 22(1)
University of Copenhagen (DK)
Openalex Percentile: Top 8%
Diet, Metabolism, and Disease
2.59
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.