Tau pathology differs by sex in Alzheimer's disease in Down syndrome
Tau pathology is significantly elevated in individuals with DS-AD, especially in females. Female DS-AD brains show markedly higher PHF1 (S396/404) and sarkosyl-insoluble tau levels compared to males. The observed sex difference in phosphorylated tau is driven by lower total tau in DS-AD males. Minimal tau pathology is present in DS without AD and in a rare partial trisomy 21 case. These findings implicate APP gene dosage in tau pathology in DS-AD.
Authors
- Xinxin Zuo
- William C. Mobley (ORCID: https://orcid.org/0000-0002-6408-9548)
- Xu‐Qiao Chen (ORCID: https://orcid.org/0000-0001-9799-7246)
Institutions
- University of California San Diego (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/alz.70838
- Primary Topic
- Down syndrome and intellectual disability research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute on Aging