Transmission of Major Depression and Bipolar Disorder to Alcohol and Other Drug Use Disorders in a Swedish National Sample: Strongest Effects From Mothers to Daughters

Findings demonstrate familial transmission of MDD and BD in parents to AUD and DUD in offspring. Affected mothers may be particularly influential. When sex-specific transmission occurred, it was consistently strongest from mother to daughter.

Authors

Kathryn Polak (ORCID: https://orcid.org/0000-0002-3571-8392)
Kenneth S. Kendler (ORCID: https://orcid.org/0000-0001-8689-6570)
Linda Abrahamsson (ORCID: https://orcid.org/0000-0002-1372-5508)
Kristina Sundquist (ORCID: https://orcid.org/0000-0001-8031-279X)
Jan Sundquist

Institutions

Virginia Commonwealth University (US)
Lund University (SE)
Icahn School of Medicine at Mount Sinai (US)

Publication Details

Journal: Journal of Studies on Alcohol and Drugs
Published: 2025-10-23
DOI: https://doi.org/10.15288/jsad.25-00009
Primary Topic: Child and Adolescent Psychosocial and Emotional Development
Type: article
Field-Weighted Citation Impact: 0.00

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article

Transmission of Major Depression and Bipolar Disorder to Alcohol and Other Drug Use Disorders in a Swedish National Sample: Strongest Effects From Mothers to Daughters

Kathryn Polak, Kenneth S. Kendler, Linda Abrahamsson, Kristina Sundquist et al.

Oct 23, 2025

Journal of Studies on Alcohol and Drugs

Child and Adolescent Psychosocial and Emotional Development

article

Transmission of Major Depression and Bipolar Disorder to Alcohol and Other Drug Use Disorders in a Swedish National Sample: Strongest Effects From Mothers to Daughters

Kathryn Polak, Kenneth S. Kendler, Linda Abrahamsson, Kristina Sundquist, Jan Sundquist

October 23, 2025article en

Abstract

Findings demonstrate familial transmission of MDD and BD in parents to AUD and DUD in offspring. Affected mothers may be particularly influential. When sex-specific transmission occurred, it was consistently strongest from mother to daughter.

Journal of Studies on Alcohol and Drugs

Virginia Commonwealth University (US), Lund University (SE), Icahn School of Medicine at Mount Sinai (US)

Openalex Percentile: Top 58%

Child and Adolescent Psychosocial and Emotional Development

DOI Open Access PDF OpenAlex

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