Multi-omics analysis of testis after long-term exposure to polystyrene nanoplastics reveals premature testicular aging and age-dependent damage in mice
Integrated with multi-omics analyses, our study collectively extends the current understanding of PS-NP-induced testicular and sperm toxicology, highlighting age- and duration-dependent risks to male reproduction. Protecting mRNA metabolism and testosterone production may help preserve reproductive capacity in young males exposed to NPs.
Authors
- Hongrui Feng (ORCID: https://orcid.org/0000-0002-0626-7270)
- Yuji Huang
- Zhenlie Huang (ORCID: https://orcid.org/0000-0001-9818-8192)
- Zicong Huang (ORCID: https://orcid.org/0009-0006-4693-4855)
- Ke Ma (ORCID: https://orcid.org/0000-0003-4942-9281)
- Maoyong Song (ORCID: https://orcid.org/0000-0002-6776-4705)
- Yuge Zhuang (ORCID: https://orcid.org/0000-0002-6564-8989)
- Xiaoyuan Zhang (ORCID: https://orcid.org/0000-0001-5130-9495)
- Wenyuan Liu (ORCID: https://orcid.org/0000-0001-9681-0507)
- Zhiming Li (ORCID: https://orcid.org/0009-0000-7497-3559)
- Zhenguo Chen (ORCID: https://orcid.org/0000-0001-5853-4548)
- Hanbin Zhang (ORCID: https://orcid.org/0000-0002-0427-0070)
- Runduan Yi
- Shipeng Ruan
- Xixian Cen
Institutions
- Third Affiliated Hospital of Guangzhou Medical University (CN)
- Zhujiang Hospital (CN)
- Research Center for Eco-Environmental Sciences (CN)
- Guangdong Academy of Medical Sciences (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Particle and Fibre Toxicology
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1186/s12989-025-00642-9
- Citations
- 4
- Primary Topic
- Microplastics and Plastic Pollution
- Type
- article
- Field-Weighted Citation Impact
- 2.01