Novel radiohybrid PET-Tracers for SST2-targeted imaging of neuroendocrine tumors
This study demonstrates a SST<sub>2</sub>-targeted radiohybrid concept using bifunctionalized DOTA as a bridging unit. N-terminal modifications with hydrophilic tripeptides improved the pharmacokinetic properties. [<sup>18</sup>F][<sup>nat</sup>Ga]rhTATE2.5 (D-Glu-D-Glu-D-Glu) compares particularly well to [<sup>18</sup>F]SiTATE regarding background clearance and tumor accumulation, with the additional advantage of radiohybrid radiolabeling.
Authors
- David Viertl (ORCID: https://orcid.org/0000-0001-5203-0939)
- Alexandra Litvinenko (ORCID: https://orcid.org/0000-0002-5070-7122)
- Philipp Spatz (ORCID: https://orcid.org/0000-0003-1718-5593)
- Margret Schottelius (ORCID: https://orcid.org/0000-0002-1928-6913)
- Mara Parzinger
- Alexander J. Wurzer (ORCID: https://orcid.org/0000-0002-3628-4688)
- Lennard Wendlinger (ORCID: https://orcid.org/0009-0005-4519-7972)
- Hans‐Jürgen Wester (ORCID: https://orcid.org/0000-0002-6655-4183)
Institutions
- Centre Hospitalier Universitaire Vaudois (CH)
- Theranostics (New Zealand) (NZ)
- Swiss Cancer Center Léman (CH)
- Technical University of Munich (DE)
Publication Details
- Journal
- European Journal of Nuclear Medicine and Molecular Imaging
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1007/s00259-025-07638-9
- Citations
- 1
- Primary Topic
- Neuroendocrine Tumor Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 1.35