Huang-Lian-Jie-Du decoction alleviates cognitive impairment in periodontitis rats through restoring microbiota-gut-brain axis and inhibiting neuroinflammation via TLR4/NF-κB pathway
HLJDD ameliorates cognitive impairment in periodontitis by modulating the microbiota-gut-brain axis, reducing neuroinflammation, and inhibiting TLR4/NF-κB activation. These findings support its potential as a novel therapeutic strategy for periodontitis-associated cognitive impairment.
Authors
- Wenbin Wu (ORCID: https://orcid.org/0000-0002-7396-1465)
- Manru Xu (ORCID: https://orcid.org/0000-0001-8981-2141)
- Furong Zhong
- Shanshan Yang (ORCID: https://orcid.org/0000-0003-4168-3496)
- Mingqi Chen (ORCID: https://orcid.org/0009-0005-4070-8825)
- Jie Li (ORCID: https://orcid.org/0000-0002-2773-6806)
- Yuemin Zhu (ORCID: https://orcid.org/0000-0001-6814-1449)
- Jinxin Chen (ORCID: https://orcid.org/0009-0006-4654-2202)
- Yun Fan (ORCID: https://orcid.org/0000-0002-6754-3232)
- Pan Ren
Institutions
- Chengdu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1186/s13020-025-01235-6
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China