Ershen Dan attenuates atherosclerosis by modulating the NOTCH1/NF-κB/NLRP3 signaling pathway to suppress M1 macrophage polarization
Twenty bioactive chemical components were identified in ESD. In vivo studies demonstrated that ESD inhibits macrophage secretion of inflammatory factors through the NOTCH1/NF-κB/NLRP3 signaling pathway, indicating its therapeutic potential for atherosclerosis. In vitro studies further revealed that ginsenoside Rg<sub>1</sub> and tanshinone II<sub>A</sub>, which are active constituents of ESD, exert anti-inflammatory effects by suppressing the NOTCH1/NF-κB/NLRP3 pathway and reducing intracellular ROS levels in macrophages, supporting their role in atherosclerosis treatment.
Authors
- Yunlun Li (ORCID: https://orcid.org/0000-0002-2129-1447)
- Hui Wang (ORCID: https://orcid.org/0000-0002-4136-0999)
- Qing Wei (ORCID: https://orcid.org/0000-0002-4433-8906)
- Lei Zhang (ORCID: https://orcid.org/0000-0002-6968-0492)
- Wenjie Zhao (ORCID: https://orcid.org/0009-0002-0759-1192)
- Wenqing Yang (ORCID: https://orcid.org/0000-0003-4622-7393)
- Shao-Hung Peng
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Affiliated Hospital of Shandong University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1186/s13020-025-01232-9
- Citations
- 1
- Primary Topic
- Atherosclerosis and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.80