The added value of PSMA PET to nomograms in identifying optimal candidates for extended pelvic lymph node dissection in intermediate-risk prostate cancer patients
Our findings suggest that integrating PSMA PET with nomograms in intermediate-risk cases could optimize patient selection for ePLND, potentially reducing unnecessary surgeries without increasing the risk of missed LNI cases. Preoperative staging with PSMA PET may play both exclusive and inclusive roles in the intermediate-risk setting. If PSMA PET shows N0, it may exclude candidates from ePLND. Additionally, when combined with nomograms, it may help select candidates for ePLND among patients who show a high risk of LNI according to risk calculators.
Authors
- Daniele Robesti (ORCID: https://orcid.org/0000-0001-6486-2169)
- Cristian Fiori
- Pasquale Rescigno (ORCID: https://orcid.org/0000-0002-4668-4765)
- Francesco Barletta (ORCID: https://orcid.org/0000-0003-3585-3217)
- Gianmario Sambuceti (ORCID: https://orcid.org/0000-0003-2979-6500)
- Michele Ortenzi
- Enrico Checcucci (ORCID: https://orcid.org/0000-0001-7901-5608)
- Alberto Briganti (ORCID: https://orcid.org/0000-0002-2178-0494)
- Carlo Terrone (ORCID: https://orcid.org/0000-0002-2492-7279)
- Matteo Bauckneht (ORCID: https://orcid.org/0000-0002-1937-9116)
- Francesco Lanfranchi (ORCID: https://orcid.org/0000-0002-6043-9627)
- Sabrina De Cillis (ORCID: https://orcid.org/0000-0002-7798-6926)
- Daniele Amparore (ORCID: https://orcid.org/0000-0001-5425-5453)
- Giorgio Gandaglia
- A. Sterrantino (ORCID: https://orcid.org/0009-0007-9409-6187)
- Simone Scuderi (ORCID: https://orcid.org/0000-0003-0071-1868)
- F. Porpiglia (ORCID: https://orcid.org/0000-0002-0752-4857)
- Arturo Chiti (ORCID: https://orcid.org/0000-0002-5806-1856)
- Edoardo Cisero
- Stefano De Luca (ORCID: https://orcid.org/0000-0002-2596-9796)
- Alessio Rizzo (ORCID: https://orcid.org/0009-0007-5438-8230)
- Alessio Signori
- Valentina Pau
Institutions
- Vita-Salute San Raffaele University (IT)
- Ospedale Policlinico San Martino (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Ospedale San Luigi Gonzaga (IT)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
- University of Turin (IT)
- University of Genoa (IT)
- Newcastle University (GB)
Publication Details
- Journal
- Minerva Urology and Nephrology
- Published
- 2025-10-01
- DOI
- https://doi.org/10.23736/s2724-6051.25.06470-5
- Citations
- 1
- Primary Topic
- Prostate Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.52