Dietary ω−3 polyunsaturated fatty acids (PUFAs) reduce cholesterol-driven non-small cell lung cancer (NSCLC) progression in mouse models of disease
Dietary lipids modulate NSCLC progression via metabolic, inflammatory, and immune pathways. ω-3 PUFA supplementation counteracts cholesterol-driven tumor promotion and augments PD-1 blockade efficacy, supporting dietary modulation as a complementary strategy to improve immunotherapy outcomes in NSCLC.
Authors
- Denis I. Trufa
- Horia Sı̂rbu
- Jonas Willar
- Kai Hildner (ORCID: https://orcid.org/0000-0001-5007-4874)
- Manfred Rauh (ORCID: https://orcid.org/0000-0002-4852-7157)
- Zuqin Yang (ORCID: https://orcid.org/0000-0003-2886-2684)
- Patrick Tausche
- Susetta Finotto (ORCID: https://orcid.org/0000-0001-7623-7977)
- Susanne Krammer (ORCID: https://orcid.org/0000-0002-1445-9555)
- Katja Hohenberger
- Mircea T. Chiriac (ORCID: https://orcid.org/0000-0002-9990-7862)
- Arndt Hartmann
- Carol Geppert
- Philipp Harre
Institutions
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Universitätsklinikum Erlangen (DE)
- Comprehensive Cancer Center Erlangen (DE)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1038/s43856-025-01193-y
- Citations
- 1
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Deutsche Forschungsgemeinschaft