Palbociclib-induced apoptotic colopathy: a case report and review of the literature

Although diarrhoea is a common side effect, palbociclib can, in rare cases, cause severe colitis with deep ulcers at video colonoscopy; internists should be aware of this underrecognized adverse effect.Histologic findings of increased epithelial apoptosis can support the diagnosis of drug-induced apoptotic colopathy.Oral budesonide, commonly used in microscopic colitis, may be an effective treatment for CDK4/6 inhibitor-induced colitis, offering a well-tolerated therapeutic option.