Semaphorin 3A and 3F Promote Lumen Expansion in TIE2-Mutated Venous Malformation
Our results demonstrate that WT EC are not recruited to the aberrant veins, suggesting that VM pathogenesis is fueled by clonal expansion of TIE2-mutant EC. Mechanistically, we show that Sema3A and Sema3F are overexpressed in TIE2-mutant EC and play a crucial role in the pathological vascular lumen expansion in VM.
Authors
- Sandra Schrenk
- Chhiring Sherpa
- Elisa Boscolo (ORCID: https://orcid.org/0000-0002-6996-0419)
- Lindsay J. Bischoff
- Yuqi Cai
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1161/atvbaha.125.323387
- Citations
- 1
- Primary Topic
- Vascular Malformations Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.39