Cardiomyocyte GC1 Mediates Estrogenic Angiogenesis in Right Heart Remodeling
We identified a novel estrogen- and cardiomyocyte GC1-dependent pathway that mitigates capillary rarefaction, maintaining normal capillary-to-cardiomyocyte ratio and preserving RV-PA coupling under RV pressure-overload. This proangiogenic, estrogen- and cardiomyocyte GC1-dependent mechanism contributes to sex-specific differences in RV remodeling and may inform the development of targeted therapies for RV dysfunction.
Authors
- Emily J. Tsai (ORCID: https://orcid.org/0000-0002-5098-1463)
- Andreas Friebe (ORCID: https://orcid.org/0000-0001-8178-3948)
- Christos Tzimas (ORCID: https://orcid.org/0000-0002-5347-6075)
- Wen Dun (ORCID: https://orcid.org/0000-0002-3687-8021)
- Ilaria Russo (ORCID: https://orcid.org/0000-0001-6432-3798)
- Nathan R. Tucker (ORCID: https://orcid.org/0000-0002-5071-4218)
- Nobuaki Fukuma (ORCID: https://orcid.org/0000-0002-5994-0668)
- Jared Kushner (ORCID: https://orcid.org/0000-0003-4821-0990)
- Charles W. Emala (ORCID: https://orcid.org/0000-0003-0248-4662)
- Michelle L Lance (ORCID: https://orcid.org/0000-0001-7607-9315)
- Yi Zhang
Institutions
- SUNY Upstate Medical University (US)
- University of Würzburg (DE)
- Columbia University Irving Medical Center (US)
- Columbia College (CA)
- Columbia University (US)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1161/circresaha.124.326070
- Citations
- 2
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.04