Danggui Buxue Decoction attenuates 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone—induced lung cancer growth in A/J mice by suppressing HIF-1α/VEGF-mediated angiogenesis
Our findings indicate that angiogenesis serves as a core mechanism driving NNK-induced lung tumorigenesis in mice. DBD attenuates tumor growth primarily by inhibiting HIF-1α/VEGF-mediated angiogenesis, with complementary contributions from restored immune homeostasis and ameliorated hypoxia.
Authors
- Zhilong Liu (ORCID: https://orcid.org/0000-0001-8196-2401)
- Sanyin Zhang (ORCID: https://orcid.org/0000-0002-1447-347X)
- Chen Wu (ORCID: https://orcid.org/0000-0001-9823-6158)
- Ying Guo (ORCID: https://orcid.org/0000-0002-0425-6666)
- Yushan Zhang (ORCID: https://orcid.org/0000-0002-3378-8522)
Institutions
- Taian City Central Hospital (CN)
- Sichuan Academy of Traditional Chinese Medicine (CN)
- First People's Hospital of Chongqing (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
- Central Academy of Fine Arts (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-10-22
- DOI
- https://doi.org/10.3389/fmed.2025.1687685
- Citations
- 1
- Primary Topic
- Medicinal Plant Pharmacodynamics Research
- Type
- article
- Field-Weighted Citation Impact
- 1.56