The role of circadian rest-activity rhythm for the link between 25-hydroxyvitamin D and type 2 diabetes: a cohort study
Our study suggests that CRAR abnormalities are linked to an elevated risk of incident T2D and subsequent mortality. These associations are mediated by blood and metabolic biomarkers, with serum vitamin D playing a significant role as the primary mediator.
Authors
- Xiao Tan (ORCID: https://orcid.org/0000-0003-3992-5812)
- Hanzhang Wu (ORCID: https://orcid.org/0009-0002-5004-5082)
- Hongliang Feng (ORCID: https://orcid.org/0000-0003-3291-7780)
- Ningjian Wang (ORCID: https://orcid.org/0000-0001-9591-6991)
- Liangkai Chen (ORCID: https://orcid.org/0000-0002-5227-4236)
- Shuai Wang (ORCID: https://orcid.org/0000-0002-0236-4591)
- Jihui Zhang (ORCID: https://orcid.org/0000-0002-4976-3039)
- Jiahe Wei
Institutions
- Uppsala University (SE)
- Uppsala University Hospital (SE)
- Guangdong University of Technology (CN)
- Chinese University of Hong Kong (HK)
- Second Military Medical University (CN)
- Shanghai Jiao Tong University (CN)
- Sir Run Run Shaw Hospital (CN)
- Shanghai Ninth People's Hospital (CN)
- Shanghai Pudong New Area Gongli Hospital (CN)
- Guangdong 999 Brain Hospital (CN)
- Huazhong University of Science and Technology (CN)
- Zhejiang University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Nutrition and Diabetes
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1038/s41387-025-00395-6
- Citations
- 1
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- Uppsala Universitet