Formulation and Characterisation of Flurbiprofen Nanogels Using Thin Film Hydration Techniques

Arthritis, a broad term used for a group of chronic and progressive disorders having inflammation of the joints, leading to pain, swelling and stiffness. The aim of the study is to develop and in-vitro evaluate a flurbiprofen nanogel formulation for anti-arthritis treatment. Flurbiprofen belongs to non-steroidal anti-inflammatory drug (NSAID). Flurbiprofen is widely used for the treatment of arthritis but having gastrointestinal side effects when administered orally. To avoid these limitations and enhance localized drug delivery, flurbiprofen nanogels were formulated using the thin film hydration technique, in which Carbopol 934 used as a gelling agent and cholesterol as a stabilizing agent. The prepared nanogel formulations were evaluated for physical appearance, pH, viscosity, spreadability, drug content, and in-vitro drug release. FTIR (Fourier Transform Infrared Spectroscopy) analysis provides evidence that Flurbiprofen and the excipients used are compatible with each other. Among all batches of nanogel formulation, the optimized formulation show desirable physicochemical properties having appropriate pH, high drug content, and enhanced spreadability. In-vitro release studies confirm that the drug follows the Higuchi model of release kinetics, having a Fickian Diffusion pattern. The results suggest that the optimised flurbiprofen nanogel formulation can be considered for effective and sustained topical delivery, having reduced frequent dosing and reducing systemic side effects. Keywords - NSAID, Nanogel, Flurbiprofen, Higuchi model, Fickian diffusion, Thin film hydration methods.