Genomic DNA methylation profile in peripheral blood of children with congenital biliary dilatation
This study presents the first comprehensive analysis of genome-wide DNA methylation in CBD, revealing significant epigenetic alterations in peripheral blood. These findings suggest that aberrant DNA methylation, particularly in genes regulating immune pathways, may play a critical role in the development of CBD and could provide valuable insights for identifying novel diagnostic biomarkers.
Authors
- Chenyao Wang (ORCID: https://orcid.org/0000-0002-0957-1956)
- Qi Feng (ORCID: https://orcid.org/0000-0001-5450-1343)
- Yuelan Zheng
- Yan Wang (ORCID: https://orcid.org/0000-0003-1761-8555)
Institutions
- Shenzhen Children's Hospital (CN)
Publication Details
- Journal
- BMC Medical Genomics
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1186/s12920-025-02223-3
- Primary Topic
- Pediatric Hepatobiliary Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Sanming Project of Medicine in Shenzhen