Case series: Transient neonatal macular retinoschisis - a developmental phenomenon in term infants
TNMR appears to be a self-limiting phenomenon. We explore its mechanistic relevance, proposing it is a benign variant of normal foveal maturation, offering new insight into this process. We consider its relevance to macular oedema in retinopathy of prematurity (ROP), suggesting a developmental continuum with changes in preterm infants. Spontaneous resolution is the key feature distinguishing TNMR from congenital conditions like XLRS. Recognition of this entity is clinically important to avoid misdiagnosis and unnecessary investigations.
Authors
- Frank A. Proudlock (ORCID: https://orcid.org/0000-0003-4913-2330)
- Ravi Purohit (ORCID: https://orcid.org/0000-0002-9727-5275)
- Irène Gottlob (ORCID: https://orcid.org/0000-0003-3217-493X)
- Lewis Smith
- Kanmin Xue (ORCID: https://orcid.org/0000-0003-0065-9131)
- Helena Lee (ORCID: https://orcid.org/0000-0002-2573-9536)
- Rachel Edminson
- Chetan K. Patel
Institutions
- Leicester Royal Infirmary (GB)
- Great Ormond Street Hospital for Children NHS Foundation Trust (GB)
- Nuffield Orthopaedic Centre (GB)
- University Hospital Southampton NHS Foundation Trust (GB)
- University of Oxford (GB)
- Ulverscroft (United Kingdom) (GB)
- Oxford University Hospitals NHS Trust (GB)
- University of Southampton (GB)
Publication Details
- Journal
- Eye
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1038/s41433-025-04082-9
- Primary Topic
- Retinopathy of Prematurity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Leicester
- University of Oxford
- Medical Research Council