Sample size estimation for the averted events ratio
As well as having important advantages of interpretation, using the AER as the primary estimand in active-control non-inferiority trials permits smaller and more cost-effective studies. Ideally, the AER should be derived via the counterfactual placebo incidence when this is practicable.
Authors
- Oliver Stirrup (ORCID: https://orcid.org/0000-0002-8705-3281)
- David Dunn (ORCID: https://orcid.org/0000-0003-1836-4446)
- David V. Glidden (ORCID: https://orcid.org/0000-0001-5888-1419)
Institutions
- University of California, San Francisco (US)
- MRC Clinical Trials Unit at UCL (GB)
- University College London (GB)
Publication Details
- Journal
- Clinical Trials
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1177/17407745251377435
- Primary Topic
- Advanced Causal Inference Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00