The importance of safe lithium plasma monitoring in older people

We consider that the current National Institute for Health and Care Excellence (NICE) guideline CG185 on bipolar disorder does not provide sufficiently specific guidance for the safe monitoring of plasma lithium levels in older people. We feel this needs correction, and laboratories across the UK should lower the range recommended for monitoring older people's lithium levels in line with guidelines from the International Society for Bipolar Disorder. This would provide a safety net in older people in order to prevent lithium toxicity without compromising efficacy.

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Publication Details

Journal
BJPsych Bulletin
Published
2025-10-23
DOI
https://doi.org/10.1192/bjb.2025.10163
Primary Topic
Bipolar Disorder and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

The importance of safe lithium plasma monitoring in older people

Kapila Sachdev, John T. O’Brien, Judy Rubinsztein, Arthur D. Stewart et al.
BJPsych Bulletin
Bipolar Disorder and Treatment
article

The importance of safe lithium plasma monitoring in older people

Kapila Sachdev, John T. O’Brien, Judy Rubinsztein, Arthur D. Stewart, Harleen Kaur Birgi, S. Willis, Clare Southwell
article en

Abstract

We consider that the current National Institute for Health and Care Excellence (NICE) guideline CG185 on bipolar disorder does not provide sufficiently specific guidance for the safe monitoring of plasma lithium levels in older people. We feel this needs correction, and laboratories across the UK should lower the range recommended for monitoring older people's lithium levels in line with guidelines from the International Society for Bipolar Disorder. This would provide a safety net in older people in order to prevent lithium toxicity without compromising efficacy.

BJPsych Bulletin
Norfolk and Suffolk NHS Foundation Trust (GB), University of Cambridge (GB), Fulbourn Hospital (GB), Craigavon Area Hospital (GB), East London NHS Foundation Trust (GB), Cambridge University Hospitals NHS Foundation Trust (GB)
Openalex Percentile: Top 64%
Bipolar Disorder and Treatment
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