Multicenter Retrospective Case Series on the Real‐World Experience With Sonidegib for the Management of Gorlin Syndrome
Our data on the use of sonidegib for GS in clinical practice show similar response rates to those reported in previous studies and improved tolerability compared to pivotal studies. Regimen modifications are frequently used in clinical practice to improve AEs. Although the alternate-day dose is the most common modification, dermatologists also resort to off-label regimens for this purpose.
Authors
- Laura García Fernández (ORCID: https://orcid.org/0000-0003-3740-5485)
- Dilson Lobo (ORCID: https://orcid.org/0000-0002-9222-863X)
- Mireia Yébenes (ORCID: https://orcid.org/0009-0009-0694-9835)
- Gemma Pérez‐Pastor
- Álvaro Martínez‐Doménech (ORCID: https://orcid.org/0000-0002-1252-1001)
- Francisco Vílchez‐Márquez (ORCID: https://orcid.org/0000-0002-0014-2741)
- Ricardo Fernández‐de‐Misa (ORCID: https://orcid.org/0000-0003-4120-9962)
- V.A. González-Delgado (ORCID: https://orcid.org/0000-0002-0330-7599)
- Cristina Ciudad Blanco
- Montserrat Bonfill Ortí
- Élia Samaniego González
Institutions
- Bellvitge University Hospital (ES)
- Hospital General Universitario Gregorio Marañón (ES)
- Hospital Universitario Nuestra Señora de Candelaria (ES)
- Hospital Universitari Sant Joan D'Alacant (ES)
- Hospital Clínico Universitario de Valencia (ES)
- Corporació Sanitària Parc Taulí (ES)
- Hospital Universitario Virgen de las Nieves (ES)
- Hospital General Universitario De Valencia (ES)
- Hospital Universitario de León (ES)
- Hospital Universitario Ramón y Cajal (ES)
Publication Details
- Journal
- Australasian Journal of Dermatology
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1111/ajd.14614
- Primary Topic
- Hedgehog Signaling Pathway Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00