The tumor microenvironment reprograms FAM227A expression: Implications for CRC metastasis and diagnostic biomarker development
Collectively, our findings reveal FAM227A as a dynamically regulated protein influenced by the TME, involved in p53 pathway modulation, and a promising circulating biomarker for cancer detection.
Authors
- Bin Yang (ORCID: https://orcid.org/0000-0003-4748-2484)
- Tianhui Pan
- Rui Wang (ORCID: https://orcid.org/0009-0003-1516-3865)
- Hongping Wang (ORCID: https://orcid.org/0000-0002-1790-540X)
- Sheng Yao (ORCID: https://orcid.org/0000-0003-1402-4153)
Institutions
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- Biochemical and Biophysical Research Communications
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1016/j.bbrc.2025.152853
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00