Chinese herbal prescription JZ-1 enhances host resistance to herpes simplex virus type 2 through regulating the MRN-ATM-CHK2 DNA damage response
The host MRN-ATM-CHK2 DDR pathway serves as a defensive mechanism against HSV-2 infection by being activated to restrict viral replication. However, HSV-2 infection simultaneously promotes MRE11 degradation, undermining this protective response. JZ-1 exerts its antiviral effects by preventing HSV-2-induced MRE11 degradation, thereby enhancing DDR activation and restricting HSV-2 infection.
Authors
- Xinwei Zhao (ORCID: https://orcid.org/0009-0006-5293-486X)
- Qingqing Shao
- Ximing Jin
- W. L. Wang
- Tong Liu (ORCID: https://orcid.org/0000-0001-5803-0905)
- Lijun Xu (ORCID: https://orcid.org/0000-0001-9515-6128)
- Yonggui Ma
- Yuhui Liu (ORCID: https://orcid.org/0009-0007-2296-4678)
- Cong Huang (ORCID: https://orcid.org/0009-0002-8307-4517)
- Wenhua Jiang
- Zhuo Chen (ORCID: https://orcid.org/0000-0001-6453-0447)
Institutions
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1016/j.jep.2025.120777
- Primary Topic
- Herpesvirus Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00