Host miRNAs regulate Escherichia coli O157 mucosal colonization through host-mucosa-attached microbiota interactions in calves
Host mechanisms regulating STEC O157 colonization are complex interplay among mucosa-attached microbiota and host miRNAs where virulence factors could modulate such crosstalk and cause differential host responses, highlighting the importance of host-microbiome-pathogen virulence factor interactions for pathogen colonization process. Video Abstract.
Authors
- Tom N. McNeilly (ORCID: https://orcid.org/0000-0001-6469-0512)
- Zhe Pan (ORCID: https://orcid.org/0000-0003-3210-3023)
- Tim Angus McAllister (ORCID: https://orcid.org/0000-0002-8266-6513)
- Mi Zhou (ORCID: https://orcid.org/0000-0001-9056-9468)
- Yanhong Chen (ORCID: https://orcid.org/0000-0002-6060-1372)
- Le Luo Guan
Institutions
- Agriculture and Agri-Food Canada (CA)
- University of British Columbia (CA)
- University of Alberta (CA)
- University College Cork (IE)
- Moredun Research Institute (GB)
- APC Microbiome Institute (IE)
- Lethbridge Research and Development Centre
Publication Details
- Journal
- Microbiome
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1186/s40168-025-02184-w
- Primary Topic
- Escherichia coli research studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Alberta
- European Commission
- Beef Cattle Research Council
- Natural Sciences and Engineering Research Council of Canada