Altered ruminal microbiome tryptophan metabolism and their derived 3-indoleacetic acid inhibit ruminal inflammation in subacute ruminal acidosis goats
This study unveiled that after SARA was induced by high-concentrate feeding, the rumen homeostasis was disrupted, and rumen fiber degradation capacity of dairy goats decreased, but the LPS synthesis capacity increased, and inflammation of the rumen epithelium was observed. However, the ruminal microbial species from the Bifidobacterium and Selenomonas genera and bacterial 3-indole acetic acid are pivotal in mitigating ruminal epithelial inflammation during SARA in dairy goats. This could potentially be attributed to the modulation of ruminal Th17 cell proportions and the inhibition of IL-17 signalling pathways. Video Abstract.
Authors
- Jinghui He (ORCID: https://orcid.org/0000-0002-0093-8897)
- Tao Liu (ORCID: https://orcid.org/0000-0001-6187-3540)
- Bing Xie (ORCID: https://orcid.org/0000-0003-2335-5966)
- Shengru Wu (ORCID: https://orcid.org/0000-0002-1046-3477)
- Xiao‐Dong Chen (ORCID: https://orcid.org/0000-0001-8698-0609)
- Lei Zhang (ORCID: https://orcid.org/0000-0003-0293-3157)
- Xiaolong He (ORCID: https://orcid.org/0000-0002-6629-3155)
- Qingqing Liu (ORCID: https://orcid.org/0000-0001-7482-2523)
- Junhu Yao (ORCID: https://orcid.org/0000-0002-0848-8392)
- Jianrong Ren
- Jingyi Xu
- Yachen Dong
Institutions
- Ningxia University (CN)
- North West Agriculture and Forestry University (CN)
- Jiangsu T-mab BioPharma (China) (CN)
Publication Details
- Journal
- Microbiome
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1186/s40168-025-02202-x
- Citations
- 3
- Primary Topic
- Ruminant Nutrition and Digestive Physiology
- Type
- article
- Field-Weighted Citation Impact
- 5.71
Funders
- National Natural Science Foundation of China
- Northwest A and F University
- National Key Research and Development Program of China