<i>N</i> -Difluoroacetylation of Sulfoximines by TFEDMA

A practical and general method for the <i>N</i>-difluoroacetylation of sulfoximines using TFEDMA is described. The reaction tolerates diverse functional groups and delivers versatile intermediates for <i>N</i>-difluoroethyl and <i>N</i>-tetrafluoroethyl derivatives. This PFAS-conscious approach enables efficient incorporation of nitrogen-fluoro functional motifs into bioactive frameworks, advancing both synthetic utility and sustainable fluorine chemistry.