Rationally Engineered Small Molecules: Pharmacophore Modeling and Molecular Docking Studies Targeting Toxic Polyglutamine (PolyQ) Repeats in Huntington’s Disease
This study presents five promising small-molecule inhibitors for HD, laying the groundwork for future therapeutic development targeting mHTT aggregation.
Authors
- Manne Munikumar (ORCID: https://orcid.org/0000-0003-1838-122X)
- Jangampalli Adi Pradeepkiran (ORCID: https://orcid.org/0000-0003-4678-6443)
- Philip Irwin Motakatla
- Amardev Rajesh Vatapatri
- Bhragavi Pasupuleti
Institutions
- Texas Tech University (US)
- Acharya Nagarjuna University (IN)
- Biotech Park (IN)
- Texas Tech University Health Sciences Center (US)
Publication Details
- Journal
- Current Drug Targets
- Published
- 2025-10-21
- DOI
- https://doi.org/10.2174/0113894501393938251006195954
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00