Phase 2 trial (NCI-COTC030) of adjuvant inhaled recombinant human IL-15 combined with amputation and adjuvant chemotherapy in dogs with appendicular osteosarcoma
Inhaled rhIL-15 combined with amputation and chemotherapy is associated with worse outcomes in dogs with OSA. Correlative assays suggest significant immunological effects of amputation and chemotherapy on immune responses. These data have important implications on novel immunotherapy strategies involving multimodality approaches including surgery and chemotherapy.
Authors
- Daniel York (ORCID: https://orcid.org/0000-0001-6286-2894)
- Michael S. Kent (ORCID: https://orcid.org/0000-0002-7703-7720)
- Anthony E. Zamora (ORCID: https://orcid.org/0000-0001-5712-5339)
- Timothy M. Fan (ORCID: https://orcid.org/0000-0003-2510-7050)
- Tamar Cohen‐Davidyan
- Amy K. LeBlanc (ORCID: https://orcid.org/0000-0001-7656-9859)
- Jessica A. Beck (ORCID: https://orcid.org/0000-0002-0145-7606)
- Amandine Lejeune (ORCID: https://orcid.org/0009-0000-8136-9210)
- Cyrus J. Sholevar
- William J. Murphy (ORCID: https://orcid.org/0000-0002-2793-401X)
- Ravi K. Shah (ORCID: https://orcid.org/0000-0003-2802-1543)
- David M. Vail (ORCID: https://orcid.org/0000-0002-1964-3693)
- Madison E. Luker
- William T. N. Culp (ORCID: https://orcid.org/0000-0001-6132-156X)
- Aryana M. Razmara (ORCID: https://orcid.org/0000-0002-3834-3442)
- Jenna H. Burton (ORCID: https://orcid.org/0000-0002-1895-8298)
- Christina Mazcko
- Kevin Woolard (ORCID: https://orcid.org/0000-0003-3588-9359)
- Robert B. Rebhun (ORCID: https://orcid.org/0000-0002-8047-3494)
- Sylvia M. Cruz (ORCID: https://orcid.org/0000-0001-9007-6639)
- Susan L. Stewart (ORCID: https://orcid.org/0000-0002-1593-440X)
- Sushant Patkar (ORCID: https://orcid.org/0000-0002-5877-0599)
- Katherine A. Skorupski (ORCID: https://orcid.org/0000-0003-0324-445X)
- Robert J. Canter (ORCID: https://orcid.org/0000-0002-3331-5418)
- Sean J. Judge (ORCID: https://orcid.org/0000-0002-1842-9468)
- Sami Al‐Nadaf (ORCID: https://orcid.org/0000-0002-9348-2293)
- Ellen E. Sparger (ORCID: https://orcid.org/0000-0001-5244-1500)
- Erich Huang (ORCID: https://orcid.org/0000-0001-5547-9408)
- Jacque C. Young
Institutions
- National Institutes of Health (US)
- Urbana University (US)
- Medical College of Wisconsin (US)
- Veterinary Medical Teaching Hospital (US)
- University of Wisconsin Carbone Cancer Center (US)
- National Cancer Institute (MY)
- National Cancer Institute (US)
- University of California Davis Medical Center (US)
- University of California, Davis (US)
- Colorado State University (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-23
- DOI
- https://doi.org/10.3389/fimmu.2025.1672790
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Frederick National Laboratory for Cancer Research
- National Institutes of Health
- University of California, Davis
- National Cancer Institute