DNase I alleviates renal inflammatory injury in MRL/lpr mice by inhibiting NETs formation
DNase I alleviates renal inflammatory injury by inhibiting the NETs/TLR4/MYD88 cell signaling axis, reducing the formation of NETs and the infiltration of immune inflammatory cells such as T cells and macrophages. These findings may provide a novel clinical prevention and treatment strategy for LN.
Authors
- Xinran Xie
- Gula Da
- Hongbin Li (ORCID: https://orcid.org/0000-0001-6127-9007)
- Yongsheng Jin (ORCID: https://orcid.org/0000-0002-1885-8318)
- Manling Zhang (ORCID: https://orcid.org/0000-0001-8250-8833)
Institutions
- Inner Mongolia Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-23
- DOI
- https://doi.org/10.3389/fimmu.2025.1656069
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Inner Mongolia Medical University
- National Natural Science Foundation of China