Distinct effect of preconditioning with p38 MAPK signals on matrix-expanded human synovium-derived stem cell chondrogenesis: sb203580 favors chondrogenic differentiation while anisomycin benefits endochondral bone formation
This study suggests that p38 MAPK pretreatment may play a key role in dECM-expanded tissue-specific stem cell-mediated cartilage regeneration. Further verification of Wnt-related regenerative mechanisms remains to be determined.
Authors
- Chaoliang Lv
- Ming Pei (ORCID: https://orcid.org/0000-0001-5710-3578)
- Ying Zhang (ORCID: https://orcid.org/0009-0009-9153-7594)
Institutions
- West Virginia University (US)
- Jining First People's Hospital (CN)
- Affiliated Hospital of Jining Medical University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-10-23
- DOI
- https://doi.org/10.3389/fcell.2025.1655408
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.00