HOXA5-mediated spatial remodeling of tumor-immune interfaces across cancers promotes AML pathogenesis
HOXA5 plays a dual role in solid versus hematologic malignancies and serves as a key spatial immune regulator. It is a robust prognostic biomarker and therapeutic target in AML, with mercaptopurine representing a promising repurposing candidate.
Authors
- Fangfang Zhong (ORCID: https://orcid.org/0000-0003-1805-566X)
- Qulian Guo (ORCID: https://orcid.org/0000-0002-5958-2258)
- C. Zhang
- Yan Zeng (ORCID: https://orcid.org/0000-0002-5496-4468)
- Tao Chen (ORCID: https://orcid.org/0000-0002-8433-2509)
- Chunyan Liu (ORCID: https://orcid.org/0000-0001-8274-0747)
- Ping Wen
Institutions
- Affiliated Hospital of Southwest Medical University (CN)
- First Affiliated Hospital of Sichuan Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-23
- DOI
- https://doi.org/10.3389/fimmu.2025.1677713
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00