Microwave ablation triggers OX40L-mediated disruption of TNFRSF4+ Treg immunosuppressive activity
This study demonstrates that MWA disrupts Treg immunosuppression, likely by activating OX40L/TNFRSF4 signaling, and favorably alters the balance of effector to suppressor cells, providing a novel rationale for combining thermal ablation with OX40-targeted immunotherapies in cancer treatment.
Authors
- Run‐Qi Guo (ORCID: https://orcid.org/0000-0001-7026-6937)
- Jie Sun (ORCID: https://orcid.org/0000-0001-8775-5032)
- Yufeng Wang (ORCID: https://orcid.org/0000-0002-8585-6996)
- Xiaoguang Li (ORCID: https://orcid.org/0000-0001-9979-053X)
- Zhi‐Xin Bie (ORCID: https://orcid.org/0000-0003-3365-0694)
- Yuanming Li (ORCID: https://orcid.org/0009-0000-9454-1614)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-23
- DOI
- https://doi.org/10.3389/fimmu.2025.1637317
- Citations
- 2
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 3.04