Lymphocyte loss and plasmacytosis are associated with IL-6- and TNF-producing cells in the spleens of fatal COVID-19 cases
These findings suggest that the spleen contributes to the inflammatory response in <i>SARS-CoV-2</i> infection, acting both as a source of inflammatory cytokines as well as a site of leukocyte, particularly lymphocyte, death both in association with the exacerbated release of IL-6 and TNF.
Authors
- Bianca Ramos Mesquita (ORCID: https://orcid.org/0000-0002-4007-873X)
- Cláudio Pereira Figueira (ORCID: https://orcid.org/0000-0001-8979-8626)
- Geraldo Gileno de Sá Oliveira (ORCID: https://orcid.org/0000-0001-6065-6480)
- Carla Pagliari (ORCID: https://orcid.org/0000-0001-6210-6917)
- Maria Brandão Tavares (ORCID: https://orcid.org/0000-0002-7549-0513)
- Jonathan Luís Magalhães Fontes
- Laetitia Pinto
- Washington L. C. dos‐Santos (ORCID: https://orcid.org/0000-0002-5075-1254)
- Esperidiana A. B. Moura (ORCID: https://orcid.org/0000-0003-3546-1643)
- Erina M. A. Hassegawa
- Reginaldo Brito (ORCID: https://orcid.org/0000-0002-8177-4301)
- Lucimar Maria Fossatti de Carvalho
- Leonardo Cardoso Gomes Baqueiro
Institutions
- Universidade Federal da Bahia (BR)
- Universidade do Estado da Bahia (BR)
- Universidade de São Paulo (BR)
- Hospital São Rafael (BR)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
- Fundação Oswaldo Cruz (BR)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-10-23
- DOI
- https://doi.org/10.3389/fcimb.2025.1645378
- Primary Topic
- COVID-19 Clinical Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior