Monocyte-driven IFN and TNF programs orchestrate inflammatory networks in antisynthetase syndrome-associated interstitial lung disease
This study identifies monocytes as central orchestrators of immune dysregulation in ASS-ILD, highlighting IFN/TNF signaling and associated transcriptional regulators as therapeutic targets.
Authors
- Jianqun Lin
- Kedi Zheng
- Miaotong Su
- Yu Fan (ORCID: https://orcid.org/0000-0002-5978-5004)
- Shaoyu Zheng (ORCID: https://orcid.org/0009-0009-9856-371X)
- Yukai Wang (ORCID: https://orcid.org/0000-0003-2468-3208)
- Guohong Zhang (ORCID: https://orcid.org/0000-0002-3856-3111)
- Weijin Zhang (ORCID: https://orcid.org/0000-0002-1477-7465)
- Fengcai Shen
Institutions
- University of Sassari (IT)
- Shantou University (CN)
- Shantou University Medical College (CN)
- Shantou Central Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-23
- DOI
- https://doi.org/10.3389/fimmu.2025.1652999
- Citations
- 1
- Primary Topic
- Inflammatory Myopathies and Dermatomyositis
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- National Natural Science Foundation of China