Design of debunking the frailty–sarcopenia–ADT axis in metastatic prostate cancer with multicomponent exercise: the FIERCE trial protocol
This first-of-its-kind study targets a vulnerable, understudied population: frail men with mPCa. If successful, our findings will establish the efficacy of a multicomponent exercise intervention on frailty and sarcopenic status, providing the foundation for future larger phase II and III trials to confirm the findings and potentially establish exercise as a safe and necessary part of the standard of care for frail metastatic prostate cancer patients.
Authors
- Maria Vamvini (ORCID: https://orcid.org/0000-0002-1532-1689)
- Matthew G. Vander Heiden (ORCID: https://orcid.org/0000-0002-6702-4192)
- Joseph A. Greer (ORCID: https://orcid.org/0000-0002-8503-8360)
- Michael P. Rosenthal
- David Johnson Einstein (ORCID: https://orcid.org/0000-0001-9163-3281)
- Christina M. Dieli‐Conwright (ORCID: https://orcid.org/0000-0001-9093-7259)
- Rebekah L. Wilson (ORCID: https://orcid.org/0000-0003-1704-3624)
- Anderson Vulczak (ORCID: https://orcid.org/0000-0002-7683-7275)
- Alicia Katherine Morgans (ORCID: https://orcid.org/0000-0002-6563-4587)
- Hajime Uno (ORCID: https://orcid.org/0000-0003-0622-8471)
- Mary K. Norris (ORCID: https://orcid.org/0000-0002-8914-1306)
- Jennie Votta
Institutions
- Brigham and Women's Hospital (US)
- Joslin Diabetes Center (US)
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- Universidade de São Paulo (BR)
- Dana-Farber Cancer Institute (US)
- Massachusetts Institute of Technology (US)
Publication Details
- Journal
- Frontiers in Sports and Active Living
- Published
- 2025-10-23
- DOI
- https://doi.org/10.3389/fspor.2025.1602123
- Citations
- 1
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Prostate Cancer Foundation