Selective targeting of glioma via the SCARB2 receptor: transcriptomic, proteomic and in vitro functional validation for Enterovirus A71 virotherapy
SCARB2 serves as a critical cellular receptor for EV-A71-mediated oncolytic activity in glioma. Elevated SCARB2 expression in GBM highlights its potential as both a therapeutic target and predictive biomarker for selecting glioma patients responsive to oncolytic EV-A71 therapy.
Authors
- Xiaofeng Yin (ORCID: https://orcid.org/0000-0001-9932-642X)
- Jinchuan Li (ORCID: https://orcid.org/0000-0002-4588-7798)
- Junjie Zhang (ORCID: https://orcid.org/0000-0002-7577-775X)
- Yi Zhang (ORCID: https://orcid.org/0000-0001-9861-4681)
- Hao Zheng (ORCID: https://orcid.org/0009-0000-6483-8433)
Institutions
- Shanxi Medical University (CN)
- Second Hospital of Shanxi Medical University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-10-23
- DOI
- https://doi.org/10.3389/fcimb.2025.1709002
- Primary Topic
- Virus-based gene therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00