Access to Divergent Indolyl Pyrrolones via [3+2] Annulation of Indolyl Hydroxamates with Phosphonium Ylides
We report a novel [3+2] cycloaddition strategy between indolyl hydroxamates and phosphonium ylides, which selectively constructs three distinct N-heterocycles: indolyl maleimides, 5-methylenepyrrolones, and 5-hydroxypyrrolones. Notably, this work reveals the unprecedented role of phosphonium ylides as two-carbon synthons in the N-heterocycle formation.
Authors
- Xin Tang (ORCID: https://orcid.org/0000-0003-0979-5455)
- Lixian Shen
- Yao‐Fu Zeng (ORCID: https://orcid.org/0000-0003-2133-378X)
- Zhen Wang (ORCID: https://orcid.org/0000-0003-4134-1779)
- Zhang Chen (ORCID: https://orcid.org/0000-0002-6072-8226)
- Jinjin Chen (ORCID: https://orcid.org/0009-0000-8385-8384)
- Yao Tian
- Dong-Xiao Jiang
- Wei Zhang (ORCID: https://orcid.org/0009-0004-4280-7563)
Institutions
- Qinghai Tibetan Hospital (CN)
- Hunan Vocational Institute of Technology (CN)
- Hengyang Academy of Agricultural Sciences (CN)
- Department of Science and Technology of Hunan Province (CN)
- University of South China (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1021/acs.orglett.5c03964
- Citations
- 1
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.94