Development of antigen multimers for detection and evaluation of CAR T cells
Dextran multimers offer a dual advantage as versatile reagents for both staining and functional analysis of CAR T cells. Their capacity to engage CARs with the specific antigen provides a valuable platform for evaluating CAR functionality, informing CAR design improvements, and enhancing therapeutic precision.
Authors
- Keerthana Ramanathan (ORCID: https://orcid.org/0000-0001-7245-9169)
- Sine Reker Hadrup (ORCID: https://orcid.org/0000-0002-5937-4344)
- Rasmus U. W. Friis
- Markus Barden (ORCID: https://orcid.org/0000-0002-4923-2254)
- Morten Hartvig Hansen (ORCID: https://orcid.org/0000-0002-8868-6152)
- Hólmfridur R. Halldórsdóttir (ORCID: https://orcid.org/0000-0002-9033-2716)
- Maria Ormhøj (ORCID: https://orcid.org/0000-0002-0997-8262)
- Nikolaj Pagh Kristensen (ORCID: https://orcid.org/0000-0002-5073-7153)
- Hinrich Abken (ORCID: https://orcid.org/0000-0002-4302-3240)
- Cecilie S. Krüger-Jensen
- Carlos Rodriguez Pardo
Institutions
- Leibniz Association (DE)
- Leibniz Institute for Immunotherapy
- Technical University of Denmark (DK)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1007/s00262-025-04134-9
- Citations
- 1
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 1.05