Identification of two distinct uveal melanoma subtypes based on the immune cell infiltration of the primary tumour
Our study reveals cellular and immunological heterogeneity within primary UM tumours. The identification of immunologically distinct tumour types, along with aggressive melanocyte subpopulations and stromal interactions, provides insight into UM pathogenesis and supports stratified immunotherapeutic approaches.
Authors
- Sally L. Owens (ORCID: https://orcid.org/0000-0001-5420-4154)
- Susan Kennedy (ORCID: https://orcid.org/0000-0001-8234-5448)
- Konstantinos Panagiotidis (ORCID: https://orcid.org/0000-0001-8681-2058)
- Achilleas Floudas
- Noel Horgan
- Gráinne Finegan
- Stefanos Tsavdaridis
Institutions
- University of Ioannina (GR)
- Royal Victoria Eye and Ear Hospital (IE)
- Dublin City University (IE)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2025-10-23
- DOI
- https://doi.org/10.1007/s00262-025-04198-7
- Citations
- 1
- Primary Topic
- Ocular Oncology and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.71