Treatment of Severe Adenovirus Infection With <scp>HAdV</scp> ‐ <scp>B21</scp> in a Young Obese Male With Normal Immunity
Adenovirus infections are usually mild, but rare serotypes like "HAdV-B21" can cause severe pneumonia even in healthy individuals. We report a 32-year-old immunocompetent obese male who developed life-threatening HAdV-B21 pneumonia (PaO<sub>2</sub>/FiO<sub>2</sub> 62 mmHg), requiring mechanical ventilation. Successful treatment included ribavirin, corticosteroids, and prone positioning, avoiding ECMO. This case demonstrates the potential severity of rare adenovirus strains and supports combined antiviral/anti-inflammatory therapy for such infections.
Authors
- Shili Zhong (ORCID: https://orcid.org/0000-0002-0922-8787)
- Zhen Wang (ORCID: https://orcid.org/0000-0002-7351-602X)
- Peng Ji (ORCID: https://orcid.org/0000-0002-5733-0604)
Institutions
- Army Medical University (CN)
- Red Cross Hospital (GR)
- First People's Hospital of Chongqing (CN)
Publication Details
- Journal
- Clinical Case Reports
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/ccr3.71109
- Primary Topic
- Virus-based gene therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00