Impact of sequential administration of detomidine, butorphanol, and midazolam on sedation, ataxia, stimulus response, and bispectral index in horses

In conclusion, the sequential addition of low-dose CRIs of butorphanol and midazolam to detomidine CRIs is associated with a stepwise increase in sedation and ataxia. Sedation score was not predicted by BIS. When sedating horses, low-dose midazolam may be added to improve sedation and reduce stimulus response, but the risk of pronounced ataxia should be considered.