Real-world survival patterns and multimodal therapy utilization in small cell lung cancer: a retrospective cohort study in a Chinese countryside hospital
This real-world study confirms that concurrent chemoradiotherapy (CCRT) and prophylactic cranial irradiation (PCI) confer survival advantages in LS-SCLC, while palliative radiotherapy yields potential benefits in ES-SCLC. Platinum sensitivity remains a crucial predictor of second-line treatment efficacy, supporting reintroduction of platinum in sensitive relapses per guideline recommendations. Conversely, irinotecan-lobaplatin combinations provided limited benefit. Findings emphasize the need for personalized treatment sequencing and improved access to standardized multimodal care in rural healthcare settings.
Authors
- Congcong Cheng
- Ming-Fang Wang (ORCID: https://orcid.org/0000-0001-7306-955X)
- Xumei Pang
- Min Yan (ORCID: https://orcid.org/0000-0002-7823-2405)
- Taosheng Huang (ORCID: https://orcid.org/0000-0001-6601-6687)
- Kai Sun (ORCID: https://orcid.org/0000-0001-8866-8838)
- Wenxiang Zhao (ORCID: https://orcid.org/0000-0002-4444-6595)
- Jiying Xu (ORCID: https://orcid.org/0000-0001-8159-5664)
- Xi Chen (ORCID: https://orcid.org/0000-0003-0248-8161)
- Peng Wang (ORCID: https://orcid.org/0000-0003-4666-9706)
- Yutao Xia
- Runqing Wang (ORCID: https://orcid.org/0000-0002-9381-1296)
- L. Ma (ORCID: https://orcid.org/0009-0002-9697-4442)
Institutions
- Yidu Central Hospital of Weifang (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-10-23
- DOI
- https://doi.org/10.3389/fonc.2025.1636533
- Primary Topic
- Lung Cancer Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00