Linarin alleviates colonic barrier dysfunction induced by enterotoxic Escherichia coli in weaned piglets by regulating the gut microbiota and metabolic pathways
These findings indicate that linarin restores colonic barrier function and intestinal microbiota homeostasis, enhancing resistance to ETEC infection along with the development and well-being of piglets after weaning. This study offers a new mechanistic understanding of how linarin confers protection against ETEC, which can promote its widespread application as a natural feed additive to replace antibiotics.
Authors
- Shenghe Li (ORCID: https://orcid.org/0000-0001-8767-6991)
- Erhui Jin (ORCID: https://orcid.org/0000-0002-5477-5317)
- Mingyang Wang (ORCID: https://orcid.org/0009-0000-3415-6968)
- Qianqian Zhang (ORCID: https://orcid.org/0000-0003-2996-2310)
- Xiaodan Liu (ORCID: https://orcid.org/0000-0001-7474-1504)
- Ji Xu
- Feng Zhang (ORCID: https://orcid.org/0000-0002-1978-3821)
- Chaofan Sun
Institutions
- Anhui University of Science and Technology (CN)
- Anhui Science and Technology University (CN)
- Anhui Academy of Agricultural Sciences (CN)
- Chuzhou University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-23
- DOI
- https://doi.org/10.3389/fimmu.2025.1631991
- Citations
- 2
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 1.61