Sex differences in the combined effect of diabetes and frailty on all-cause mortality in community-dwelling older adults
Diabetes and frailty increase mortality risk in both older women and men, with an additive interaction in women. These findings support sex-specific risk stratification and emphasize the need for mechanistic research to inform targeted interventions.
Authors
- Natalie Ebert (ORCID: https://orcid.org/0000-0002-4463-3315)
- Nina Mielke (ORCID: https://orcid.org/0000-0002-8951-9823)
- Elke Schäeffner (ORCID: https://orcid.org/0000-0002-7925-4577)
- Muhammad Barghouth (ORCID: https://orcid.org/0000-0002-5721-9367)
- Alice Schneider (ORCID: https://orcid.org/0000-0001-5480-2971)
- Johnathan A. Kaiser (ORCID: https://orcid.org/0000-0001-5339-3387)
- Daris Ferrari (ORCID: https://orcid.org/0000-0002-1941-7549)
Institutions
- Humboldt-Universität zu Berlin (DE)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-10-23
- DOI
- https://doi.org/10.3389/fendo.2025.1670278
- Primary Topic
- Frailty in Older Adults
- Type
- article
- Field-Weighted Citation Impact
- 0.00