Combination CBD/THC in the management of chemotherapy-induced peripheral neuropathy: a randomized double blind controlled trial
The primary analysis showed no between-group difference in CIPN symptoms. The secondary analysis indicated that CBD with THC could improve sensory impairment and might increase touch and vibration sense, although these findings require confirmation in a future, more fully powered study. Nonetheless, our results show that combination CBD/THC can be safely delivered to participants with CIPN and suggest that these cannabinoids should be further investigated for this indication.
Authors
- Shoichi Shimamoto
- Robin M. Ciocca
- J Gary (ORCID: https://orcid.org/0009-0009-1682-3208)
- Marisa C. Weiss (ORCID: https://orcid.org/0000-0002-6955-4939)
- Lisa Saeed
- Jennifer L. Sabol
- Katherine M. DiGuilio
- Katherine Aliano Ruiz
- Paul Gilman (ORCID: https://orcid.org/0000-0002-7983-4942)
- Jessica Burrell
- Sarah Windawi
- Sharon Larson (ORCID: https://orcid.org/0000-0001-5625-8500)
- Julianne Hibbs
- John H. Marks (ORCID: https://orcid.org/0000-0002-5977-0603)
- Eric Zeger
- Arezoo Ghaneie
- Stephanie Kjelstrom (ORCID: https://orcid.org/0000-0003-0933-4472)
- Muath Giaddui
- Ebuwa Erebor
- Gabrielle Bidas
- Sara Jane Ward
- Diana Martinez (ORCID: https://orcid.org/0000-0003-3910-7537)
- David O. Holtz
- Zonera Ali
- Aarthi Shevade
- Sam Meske
Institutions
- Main Line Health (US)
- Texas Medical Center (US)
- Thomas Jefferson University (US)
- Lankenau Institute for Medical Research (US)
- Columbia University Irving Medical Center (US)
- Baylor University Medical Center (US)
- Lankenau Medical Center (US)
- New York Psychoanalytic Society and Institute (US)
- Baylor School (US)
- Breast Center (CH)
- Temple University (US)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-10-23
- DOI
- https://doi.org/10.3389/fonc.2025.1590168
- Primary Topic
- Cancer Treatment and Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute on Drug Abuse
- National Center for Complementary and Integrative Health