SUN-583 Obesity-Associated Cancer Mortality in the United States (1999-2020): A National Epidemiological Analysis

Abstract Disclosure: A. Ullah: None. R. Haider: None. F. Ahmed: None. A. Fayyaz: None. R. Ali: None. K. Aman: None. H. Abid: None. Y. Rasheed: None. I. Nayyab: None. N. Gohar: None. O.M. Kamel: None. T. Mirza: None. M. Abid: None. M. Bakr: None. S. Eltawansy: None. Introduction: Obesity is a significant risk factor for multiple cancers, contributing to significant mortality. This study examines trends in obesity-associated cancer mortality in the U.S. from 1999 to 2020, using age-adjusted mortality rates (AAMR) stratifying data by demographics and geographics to identify high-risk populations for targeted public health interventions. Methods: CDC WONDER mortality data were analyzed for 33,572 obesity-related cancer deaths (1999-2020). AAMRs per million were calculated, and trends were assessed using Joinpoint regression to determine annual percent change (APC) and average annual percent change (AAPC), with statistical significance at p < 0.05. Results: Mortality trends increased from an AAMR of 3.73 (95% CI: 3.45-4.01) in 1999 to 13.52 (13.08-13.97) in 2020 with most of the deaths occuring in medical facilities (47.7%). The overall AAPC was 5.92% (5.23-6.44, p < 0.00001), with a sharp increase from 2018-2020 (APC: 19.37%, 9.59-24.20, p < 0.00001). Gender based analysis revealed that the average AAMR was 7.22 (7.12-7.32) for females with AAPC (5.37%, 4.58-5.98, p< 0.0001) and 6.59 (6.48-6.70) for males with AAPC (6.75%, 6.23-7.24; p < 0.00001). Hispanics had the highest AAPC (6.31%, 3.78-9.29, p < 0.001) with the lowest being in Blacks (5.37%, 4.70-6.05, p < 0.00001). The ≥65 group had a significantly higher AAMR (20.82, 20.52-21.11), peaking at 41.54 (39.82-43.26) in 2020 with an AAPC of (6.26%, 5.39-6.90, p < 0.00001) compared to 25-64 age group. Regionally, the Midwest had the highest AAMR (7.96, 7.79-8.13) with an AAPC (6.01%, p < 0.00001), while the Northeast had the lowest (5.7, 5.54-5.85) with an AAPC (5.56%, p < 0.00001). State-level analysis revealed that Vermont, Minnesota and Oklahoma had AAMRs above the 90th percentile, while Utah, Alabama and Virginia were below the 10th percentile. Both rural and urban areas exhibited increasing mortality trends (AAPC: urban 6.03%, 5.33-6.60; rural 6.98%, 5.97-8.75, p < 0.00001). Conclusion: Obesity-related cancer mortality has risen significantly, with disparities across gender, race, age, and geography. The highest mortality rates were observed in older adults, rural populations, and the Midwest. Females bore a higher burden, and racial minorities, particularly American Indians and African Americans, were disproportionately affected. Given these trends, targeted public health interventions, including preventive measures, early screening, and equitable healthcare access, are pivotal. Presentation: Sunday, July 13, 2025