SAT-796 REMS Suitability in Endocrine-Related Bone Disorders

Abstract Disclosure: E. Luna: None. Background: Endocrine disorders such as hypothyroidism, Hashimoto's thyroiditis, diabetes mellitus (T2DM), and rare endocrine diseases significantly affect bone health, leading to reduced bone mineral density (BMD) andincreased risk of fracture. These conditions disrupt bone remodeling and microarchitecture, leading to skeletal fragility that is often underdiagnosed and undertreated by traditional diagnostic tools, emphasizing the need for advanced diagnostic approaches to ensure effective prevention, monitoring, and personalized treatment. Objectives: This review aims to evaluate the suitability of Radiofrequency Echographic Multi-Spectrometry (REMS) for diagnosing and monitoring bone health in endocrine-related bone disorders, focusing on potential advantages over conventional imaging techniques. Methods: A systematic literature review was conducted to evaluate REMS’s performance in assessing bone health in endocrine-related conditions, including T2DM, hypothyroidism, Hashimoto’s thyroiditis, and rare endocrine diseases. Studies investigating REMS-derived parameters such as BMD and Fragility Score (FS), as well as their correlation with fracture risk, were included. Particular attention was given to REMS’s ability to detect microarchitectural changes that are not evident with DXA. Results: Endocrine disorders negatively impact bone health, shown in recently published clinical studies by measuring BMD, T-Score, and Fragility Score. In T2DM, where normal or elevated BMD masks an increased fracture risk due to microarchitectural deterioration, REMS effectively detected compromised bone quality that DXA was unable to identify. Similarly, in thyroid disorders like hypothyroidism and Hashimoto’s thyroiditis, REMS revealed skeletal fragility linked to altered collagen quality and bone turnover. REMS has proven effective in identifying bone fragility in rare endocrine diseases, improving fracture risk prediction and enhancing clinical management. Conclusion: REMS offers an innovative tool for assessing bone health in endocrine-related disorders by addressing the limitations of traditional techniques. Its ability to evaluate both bone quantity and quality improves fracture risk prediction, particularly in challenging cases such as T2DM and thyroid dysfunction including hypothyroidism, and Hashimoto's thyroiditis. REMS allows earlier diagnosis and personalized management, advancing preventive care and improving outcomes in patients with endocrine-related bone fragility Presentation: Saturday, July 12, 2025