MON-355 Gender and Racial Disparities in Hospitalized Patients with Thyroid Disease: Insights into Outcomes and Healthcare Utilization from National inpatient sample ( 2016-2020)

Abstract Disclosure: S. Alrosan: None. M. Al-Ahmad: None. B. barthel: None. Background: Thyroid diseases (hypothyroidism and hyperthyroidism) are common endocrine conditions with systemic manifestations. Gender and racial disparities in healthcare are well known, but the impact on hospital outcomes in patients admitted with thyroid disease is unclear. This study looks at mortality, health care resources utilization, and complications in hospitalized patients with thyroid disease by gender and race using NIS (2016-2020). Methods: This is a retrospective study of adult patients admitted with a primary diagnosis of hypothyroidism or hyperthyroidism from NIS (2016-2020) using ICD-10 codes. Patients were stratified by gender and race. The outcomes were in-hospital mortality, length of stay (LOS), total cost of care (TOC). Secondary outcomes were myxedema coma, thyroid storm, venous thromboembolism (VTE), acute myocardial infarction (AMI), atrial fibrillation (AF), pericardial tamponade. Multivariable logistic and linear regression were used to calculate adjusted odds ratios (aOR) and mean differences (aMD) after adjusting for demographics and comorbidities. Results: Of 77,915 patients admitted with thyroid disease, 56,925 (73%) were female and 21,050 (27%) were male. Racial distribution was 40,935 (54%) White, 18,245 (24.1%) African American, and 10,325 (13.6%) Hispanic. Mortality was lower in females than males (1.2% vs. 2.0%; aOR 0.7, 95% CI 0.51-0.90, p=0.037). Females had lower odds of AF compared to males (aOR 0.68, 95% CI 0.62-0.75, p < 0.001). No differences were seen for myxedema coma (aOR 0.74, p=0.201), thyroid storm (aOR 1.34, p=0.437), VTE (aOR 0.78, p=0.273), AMI (aOR 1.05, p=0.88). LOS (aMD -0.03 days, p=0.787) and TOC (aMD -$1,527, p=0.255) were similar between genders. Compared to Whites, African Americans had similar mortality (aOR 0.97, p=0.923), lower AF (aOR 0.87, p=0.029) but higher odds of other arrhythmias (aOR 1.28, p=0.009). Hispanics had lower mortality (aOR 0.63, p=0.208) but higher AMI (aOR 1.65, p=0.039). African Americans and Hispanics had lower odds of respiratory failure (aOR 0.71, p<0.001 and aOR 0.75, p=0.02, respectively). Hispanics had shorter LOS than Whites (aMD -0.56 days, p<0.001), however, TOC was not significant. Conclusion: There is a disparity in hospital outcomes among the races and genders. Females had lower mortality and AF than males. African Americans and Hispanics had different cardiac and respiratory outcomes Further research is needed to understand race-related differences, investigate underlying mechanisms and develop targeted interventions to improve outcomes. Presentation: Monday, July 14, 2025