SAT-049 Endocrine Complications After Brain Tumor Treatment in Pediatric Patients

Abstract Disclosure: E. Seeley: None. P. Tiwana: None. M.E. Patterson: None. Brain tumors are a common neoplasm in pediatric patients. Modalities to treat brain tumors include surgical resection, chemotherapy, and radiation therapy. These can lead to disruption of the hypothalamic-pituitary axis and, in turn, development of a variety of central endocrinopathies. Age at diagnosis, radiation exposure, and tumor location have been found to be associated with the development of endocrine complications. The goal of this study was to identify the incidence, timing, and factors associated with development of endocrine complications after treatment of brain neoplasms in pediatric patients. This IRB-approved retrospective chart review collected data from patients seen in a multidisciplinary neuro-oncology clinic at our institution. Data included age at diagnosis, treatment modalities, type and dose of radiation, and incidence and timing of development of endocrine complications after treatment. We compared patients with endocrine complications to those without in order to determine what factors may be associated with development of endocrinopathies after treatment. A total of 52 patients were seen in clinic between 11/2022 and 11/2024 and received treatment for their neoplasm. Of these, 28/52 (53.8%) were female and mean age at diagnosis was 5.34 years. Treatment modalities included radiation therapy in 37/52 (71.1%), chemotherapy in 48/52 (92.3%), and surgical resection in 40/52 (76.9%). A total of 29/52 (55.7%) patients developed endocrine complications during the follow up period. There was not an association between radiation exposure, photon vs. proton therapy, or maximum radiation dose and the development of endocrinopathies. There was an association between craniospinal radiation and the development of endocrinopathies compared to other areas of radiation exposure (48.3% vs 25%, p = 0.021). Growth hormone deficiency (65.5%), puberty abnormalities (48.3%), and hypothyroidism (48.3%) were the most common endocrine complications. Average time to development of endocrine complications was 3.89 years from the start of treatment. Given the large portion of children and adolescents who develop one or more endocrine complications after treatment for brain neoplasms, it is imperative to screen and follow these patients closely. Those who receive craniospinal radiation specifically may be at higher risk of developing complications. Presentation: Saturday, July 12, 2025