MON-819 Burden of Type 1 and Type 2 Diabetes Mellitus in the United States, Analysis using the Global Burden of Disease Database

Abstract Disclosure: P. Pandey: None. S. Parajuli: None. R. Bohra: None. N. Trivedi: None. Introduction According to data from the 2017–2020 National Health and Nutrition Examination Survey, approximately 37.3 million people, or 11.3% of the U.S. population, have diabetes. The prevalence of both type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) has significantly increased over the past three decades. This study analyzes trends in the burden of diabetes in the United States from 1990 to 2021 Methods Using the Global Burden of Disease (GBD) results tool, we studied the age-standardized incidence, prevalence, and mortality rates of T1DM and T2DM between 1990 and 2021. GBD is a comprehensive global study coordinated by the Institute for Health Metrics and Evaluation (IHME). Unlike the National Health and Nutrition Examination Survey (NHANES), GBD estimates the prevalence, incidence, and burden of diseases and injuries worldwide, across countries and regions. Results In 2021, the prevalence of T2DM was 44.8 million (95% uncertainty interval [UI], 41-46 million), while T1DM affected 2.1 million individuals (95% UI, 1.7-2.5 million) in the United States. From 1990 to 2021, the prevalence of T2DM increased by 158% (95% UI, 141%-175%), and the incidence rose by 153% (95% UI, 140%-168%) (Figure 1). West Virginia had the highest prevalence rate of T2DM at 10,393 per 100,000 (95% UI, 9766-11057) (Figure 2) and an incidence rate of 544 per 100,000 (95% UI, 507-577). For T1DM, Utah reported the highest prevalence rate at 649 per 100,000 (95% UI, 554-768) and the highest incidence rate at 18.48 per 100,000 (95% UI, 15.6-21.5). West Virginia also had the highest mortality rate for T2DM at 20.37 per 100,000 (95% UI, 17.23-23.62) and 1.51 per 100,000 (95% UI, 1.28-1.75) for T1DM. The mortality rates from T2DM peaked in the early 2000s and gradually decreased, however, the DALYs rates continue to rise (Figure 4,5) Conclusions Our study indicates that the burden of T2DM and T1DM has markedly increased over the last three decades. Diabetes mellitus significantly affects individuals' health and quality of life while also imposing a substantial economic burden on society. These findings underscore the need for tailored, state-specific public health strategies to prevent diabetes effectively. Presentation: Monday, July 14, 2025